Selected by NASA in March 1992, Lawrence reported to the Johnson Space Center in August 1992. She flew as the ascent/entry flight engineer and blue shift orbit pilot on STS-67 (March 2–18, 1995). Because of her knowledge and experience with Mir systems and with crew transfer logistics for the Mir, she flew on STS-86 (September 25 to October 6, 1997) and STS-91 (June 2–12, 1998).
